Peptide Database

Peptide NameProkineticin Bm8-b

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length77 amino acids

Chemical FormulaC335H539N107O110S9

DescriptionStandard

        AVITGVRDRDAQCGSGTCCAASAFSRNIRFCVPLGNNGEECHPASHKVPYNGKRLSSLCPCNTGLTCSKSGEKYQCS
    

Molecular Weight8114.10 Da

Isoelectric Point (pI)8.66

Net Charge (pH 7.0)3.89

Net Charge (pH 7.4) 3.45

Charge Density (pH 7.0) 0.0505

GRAVY Index-0.37

Hydrophobic Moment 0.62

Boman Index-0.08

Instability Index34.82

Aliphatic Index 53.25

Aromaticity 0.0519

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3502.28

LogP -51.24

H-bond Donors 131.0

H-bond Acceptors 125.0

Rotatable Bonds 264.0

Heavy Atoms 561.0

Ring Count 10.0

Amide Bonds 83.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0012160 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bm8

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

TargetDRG neurons

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0099905 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bm8

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Targetguinea-pig gastrointestinal (GI) smooth muscle

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0424378 VERIFIED: YES

Provenance & Taxonomy

OrganismBombina maxima [Animal]

FamilyProkineticin Bm8

Tax ID161274

Structure & Mods

Configlinear peptide with reported disulfide constraint [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide13-31; 18-59; 41-67; 61-76

Bio-Activity Profile

Function

Analgesic Pronociceptive Neuropeptide Neuromodulator Myotropic Receptor modulation Immunomodulatory

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour