Peptide Database

Peptide NamePotassium channel toxin HgeTx1

Function Ontology

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC157H271N53O46S10

DescriptionStandard

        TGTSCISPKQCTEPCRAKGCKHGKCMNRKCHCMLCL
    

Molecular Weight3957.81 Da

Isoelectric Point (pI)9.10

Net Charge (pH 7.0)5.49

Net Charge (pH 7.4) 5.07

Charge Density (pH 7.0) 0.1525

GRAVY Index-0.44

Hydrophobic Moment 0.57

Boman Index-0.19

Instability Index73.32

Aliphatic Index 35.28

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1600.13

LogP -21.39

H-bond Donors 64.0

H-bond Acceptors 64.0

Rotatable Bonds 134.0

Heavy Atoms 266.0

Ring Count 4.0

Amide Bonds 37.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0357320 VERIFIED: YES

Provenance & Taxonomy

OrganismHadrurus gertschi [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide5-25; 11-30; 15-32; 20-34

Bio-Activity Profile

Function

Toxin

Targetreversibly the Shaker B K-channels

Activity0.052 μM

MethodKD