Peptide Database

Peptide NameCurvacin A / sakacin A

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC190H285N53O58S3

DescriptionStandard

        RSYDNGIYCNNSKCWVNWGEAKENIAGIVISGWASGLAGM
    

Molecular Weight4335.81 Da

Isoelectric Point (pI)6.17

Net Charge (pH 7.0)-0.26

Net Charge (pH 7.4) -0.50

Charge Density (pH 7.0) -0.0064

GRAVY Index-0.17

Hydrophobic Moment 0.36

Boman Index0.14

Instability Index23.57

Aliphatic Index 73.25

Aromaticity 0.1250

Extinction Coeff. Reduced 19480.00

Extinction Coeff. Oxidized 19605.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1808.26

LogP -19.53

H-bond Donors 65.0

H-bond Acceptors 61.0

Rotatable Bonds 140.0

Heavy Atoms 304.0

Ring Count 8.0

Amide Bonds 44.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0231142 VERIFIED: YES

Provenance & Taxonomy

OrganismEnterococcus faecium [Bacterium]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)