Peptide Database

Peptide NameBrevinin-2GRa

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity

Venom / Toxin ▸ General toxin ▸ Toxic

Standard StatusStandard

Sequence Length33 amino acids

Chemical FormulaC146H252N40O46S2

DescriptionStandard

        GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC
    

Molecular Weight3367.93 Da

Isoelectric Point (pI)9.31

Net Charge (pH 7.0)2.74

Net Charge (pH 7.4) 2.50

Charge Density (pH 7.0) 0.0830

GRAVY Index0.43

Hydrophobic Moment 0.45

Boman Index0.14

Instability Index11.63

Aliphatic Index 112.42

Aromaticity 0.0303

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1406.78

LogP -17.67

H-bond Donors 51.0

H-bond Acceptors 51.0

Rotatable Bonds 116.0

Heavy Atoms 234.0

Ring Count 1.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0354126 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana jingdongensis [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0354388 VERIFIED: YES

Provenance & Taxonomy

OrganismRana grahami [Animal]

FamilyBrevinin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide27-33

Bio-Activity Profile

Function

Antimicrobial Antifungal

Targetand C. candida

Activity19 μM

MethodMIC

RECORD: Rec_0362626 VERIFIED: YES

Provenance & Taxonomy

OrganismOdorrana jingdongensis [Animal]

FamilyBrevinin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetExtended-spectrum-lactamases Escherichia coli

Activity128 μg/mL

MethodMIC

RECORD: Rec_0382131 VERIFIED: YES

Provenance & Taxonomy

OrganismRana grahami [Animal]

FamilyBrevinin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermCyclization

Disulfide27-33

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal

TargetEscherichia coli

Activity12.5 μM

MethodMIC

RECORD: Rec_0396742 VERIFIED: YES

Provenance & Taxonomy

OrganismRana grahami [Animal]

FamilyEsculentin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative

TargetCandida albicans

Activity100 μM

MethodMIC

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