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MYP_146084
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Basic Information
Brevinin-2GRa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
33 amino acids
C146H252N40O46S2
Standard
Sequence
GLLDTFKNLALNAAKSAGVSVLNSLSCKLSKTC
Physicochemical Analysis
3367.93 Da
9.31
2.74
2.50
0.0830
0.43
0.45
0.14
11.63
112.42
0.0303
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1406.78
-17.67
51.0
51.0
116.0
234.0
1.0
35.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213434 VERIFIED: YES
Provenance & Taxonomy
Odorrana margaretae [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-33
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
140.0 μM
HC50
PaperJ.M. Conlon et al. / Peptides 27 (2006) 2111-2117. Antimicrobial peptides from diverse families isolated from the skin of the Asian frog, Rana grahami PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0218261 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-33
Bio-Activity Profile
Antimicrobial Antifungal
Staphylococcus aureus MRSA
19-50 μM
MIC
PaperAntimicrobial peptides from diverse families isolated from the skin of the Asia frog, Rana Grahami
RECORD: Rec_0230272 VERIFIED: YES
Provenance & Taxonomy
Rana grahami [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-33
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
140 μM
LC50
PaperAnti-infection peptidomics of amphibian skin. Mol Cell Proteomics. 2007 May;6(5):882-94. doi: 10.1074/mcp.M600334-MCP200. PMID: 17272268. PMID16621155;17272268 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
RECORD: Rec_0237456 VERIFIED: YES
Provenance & Taxonomy
Odorrana jingdongensis [Animal]
Brevinin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Methicillin-resistant Staphylococcus aureus
64 μg/mL
MIC
PMID22917879 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22917879/
RECORD: Rec_0237838 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
140 μM
LC50
Paperhttps://pubmed.ncbi.nlm.nih.gov/16621155/ PMID16621155 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16621155/
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