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MYP_145995
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Basic Information
Urotensin-2
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasoconstrictor activity
Hormonal / Endocrine ▸ Hormone peptide
Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Neuropeptide activity ▸ Vasoactive neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Cell-cell communication
Standard
11 amino acids
C64H87N13O18S2
Standard
Sequence
ETPDCFWKYCV
Physicochemical Analysis
1390.58 Da
4.37
-1.18
-1.39
-0.1076
-0.31
0.36
0.08
-4.62
26.36
0.2727
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
502.40
-1.97
19.0
19.0
39.0
97.0
5.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0079589 VERIFIED: NO
Provenance & Taxonomy
Homo sapiens [Animal]
Urotensin-2
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-10
Bio-Activity Profile
Hormone Vasoactive neuropeptide
RECORD: Rec_0115995 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Urotensin
9606
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-10
Bio-Activity Profile
Hormone Endocrine Vasoactive Vasoconstrictor Cardiovascular Myotropic Receptor modulation
Mammalian: 1 hour; Yeast: 30 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Urotensin II (Homo sapiens): PMID 12088848 PMID12088848 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12088848/
RECORD: Rec_0191944 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Vasoconstrictor
PaperAmes R. S. et al.. Human urotensin II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.Nature, 401, 282-286.
RECORD: Rec_0246007 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0266006 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Orphan Receptor Gpr14 Agonist
PaperAmes R. S. et al.. Human urotensin II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.Nature, 401, 282-286.
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