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MYP_145994
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Basic Information
Enkelytin
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Analgesic
Neurological / Signaling ▸ Analgesic/opioid activity ▸ Opioid
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Pain modulation ▸ Pronociceptive activity
Regulatory peptide ▸ Biological modulation
Standard
29 amino acids
C148H218N34O51S2
Standard
Sequence
FAEPLPSEEEGESYSKEVPEMEKRYGGFM
Physicochemical Analysis
3353.64 Da
4.27
-5.22
-5.44
-0.1800
-1.11
0.54
-0.11
85.35
26.90
0.1379
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1365.24
-11.59
45.0
48.0
110.0
235.0
7.0
28.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0015579 VERIFIED: YES
Provenance & Taxonomy
Pantholops hodgsonii [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0039399 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus luteus
0.2 - 0.4 μM
MIC
PMID8654396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8654396/
RECORD: Rec_0068947 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/
RECORD: Rec_0076886 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Micrococcus luteus
0.2-0.4 μM
MIC
PMID6952189;8654396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/6952189/
RECORD: Rec_0133444 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Enkelytin
9913
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
15:Phosphoserine
Bio-Activity Profile
Antimicrobial Antibacterial Analgesic Pronociceptive Neuropeptide Neuromodulator Receptor modulation
Mammalian: 1.1 hour; Yeast: 3 min; E. coli: 2 min
PaperSource-linked PubMed record(s) for Enkelytin (Bos taurus): PMID 8654396 PMID8654396 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8654396/
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