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MYP_145970
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Basic Information
Brevinin-1Sb
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
24 amino acids
C121H196N28O26S2
Standard
Sequence
FLPAIVGAAGKFLPKIFCAISKKC
Physicochemical Analysis
2523.15 Da
9.70
3.74
3.50
0.1557
1.06
0.59
0.37
15.97
110.00
0.1250
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
839.35
-3.11
30.0
32.0
81.0
177.0
5.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0051761 VERIFIED: YES
Provenance & Taxonomy
Lithobates sphenocephalus [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Non-hemolytic
Gram-negative bacteria
PMID10604597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10604597/
RECORD: Rec_0105578 VERIFIED: NO
Provenance & Taxonomy
Rana sphenocephala [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperPatent US 7862826 B2 Evidence URLhttps://patents.google.com/patent/US7862826B2/en PatentUS 7862826 B2
RECORD: Rec_0116107 VERIFIED: YES
Provenance & Taxonomy
Lithobates sphenocephalus [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial
PaperJ.M. Conlon et al. / Journal of Peptide Research 54 (1999) 522-527. Peptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala Evidence URLhttps://www.uniprot.org/uniprotkb/P82905/entry
RECORD: Rec_0223919 VERIFIED: YES
Provenance & Taxonomy
Rana sphenocephala [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
pathogenic chytrid fungus B. dendrobatidis
10 μM
MIC
PaperPeptides with antimicrobial activity of the brevinin-1 family isolated from skin secretions of the southern leopard frog, Rana sphenocephala.
RECORD: Rec_0237250 VERIFIED: YES
Provenance & Taxonomy
Amphibia [Animal]
Brevinin
8292
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial
PMID10604597 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10604597/
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