Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length499 amino acids

Chemical FormulaC2542H3951N641O735S16

DescriptionStandard

        MRTRTVQVLWGCFFLWNLYISTSETVYPGIKARATQRALDYGVQLGMEMIEQMVKEKDIPDLEGSESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKVLTNHGTANISTDWEVKSPLFQDSGGAHLFLSGVYFTGVVILARNDFGHPILKLQDCYAQVSHAHVSFSGELSILYNSFAEPMEKPILKNLNEMLCPIITSEVEALKTNLSMLEVLTKIDNYTVLDYSLISSPEITENHIDLNLKGVFYPLDNLSDPPFSPLPFELPKRSDSMLYIGISEYFLKSASFAHFAAGAFNVTLSTEEISKHLVQNSQGVGNLLSRIAEIYILSQPFMVRIMATEPPVINLLPGNFTLDIPASIMLLTKFENSTAETIVSMDFVRLQEQGLPVASTSVSLAILGQRLICSLSLNRFRLSLPESNHSNVEVLRFENILSSILHFGVLPLANAKLQQGLPLPNPYNLSLVNSNIEVFERTGFYGWEGLDLRNWQWRGKPAP
    

Molecular Weight55764.46 Da

Isoelectric Point (pI)5.24

Net Charge (pH 7.0)-13.59

Net Charge (pH 7.4) -14.49

Charge Density (pH 7.0) -0.0272

GRAVY Index0.09

Hydrophobic Moment 0.67

Boman Index0.16

Instability Index39.62

Aliphatic Index 103.13

Aromaticity 0.1022

Extinction Coeff. Reduced 56840.00

Extinction Coeff. Oxidized 57090.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0140502 VERIFIED: NO

Provenance & Taxonomy

OrganismGalemys pyrenaicus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence