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MYP_145871
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Basic Information
Cycloviolin-A (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
31 amino acids
C137H224N38O40S6
Standard
Sequence
GVIPCGESCVFIPCISAAIGCSCKNKVCYRN
Physicochemical Analysis
3235.86 Da
8.33
1.70
1.40
0.0549
0.68
0.29
0.21
28.76
84.84
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1237.08
-14.08
48.0
48.0
102.0
221.0
4.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0345601 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
multiple disulfide bonds reported, sites not specified
Bio-Activity Profile
Antimicrobial Antiviral Anti-HIV
HIV-1
0.13 μM
EC50
PaperPubMed PMID 10813905 PMID10813905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0359509 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-21; 9-23; 14-28
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0379353 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-21; 9-23; 14-28
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic Anticancer
CEM-SS cells
0.56 μM
IC50
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
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