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MYP_145871
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Basic Information
Cycloviolin-A (Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
31 amino acids
C137H224N38O40S6
Standard
Sequence
GVIPCGESCVFIPCISAAIGCSCKNKVCYRN
Physicochemical Analysis
3235.86 Da
8.33
1.70
1.40
0.0549
0.68
0.29
0.21
28.76
84.84
0.0645
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1237.08
-14.08
48.0
48.0
102.0
221.0
4.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0180480 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0224157 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Cyclotide
Structure & Mods
Backbone-cyclized cyclotide scaffold with cystine-knot family annotation [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV
PMID10813905 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0227625 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]
Defensin
341676
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
5-21, 9-23, 14-28
Disulfide bonds between Cys5 and Cys21, Cys9 and Cys23,Cys14 and Cys28.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.13 μM
EC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
RECORD: Rec_0244316 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
5-21; 9-23; 14-28
Bio-Activity Profile
Antimicrobial Antiviral
HIV inhibition the cytopathic effects of HIV-1 infection in cultured human T-lymphoblast (CEM-SS) cells
0.13 μM
EC50
PaperPubMed PMID: 10813905 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10813905;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10813905/
RECORD: Rec_0276386 VERIFIED: YES
Provenance & Taxonomy
Leonia cymosa [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16735513 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16735513/
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