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MYP_145837
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Basic Information
Esculentin-1S (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
46 amino acids
C212H364N58O58S4
Standard
Sequence
GLFSKFAGKGIKNMIIKGIKGIGKEVGMDVIRTGIDVAGCKIKGEC
Physicochemical Analysis
4781.77 Da
9.63
4.74
4.49
0.1030
0.25
0.70
0.15
-13.68
99.57
0.0435
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1875.63
-15.97
67.0
67.0
174.0
332.0
2.0
46.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038698 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Esculentin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus FDA 209P
3 μM
MIC
PMID16427248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16427248/
RECORD: Rec_0056445 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0256696 VERIFIED: YES
Provenance & Taxonomy
Odorrana schmackeri [Animal]
Esculentin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
40-46
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
1.7 μM
MIC
PaperT. Chen et al. / Genomics 87 (2006) 638-644. Cloning from tissue surrogates: Antimicrobial peptide (esculentin) cDNAs from the defensive skin secretions of Chinese ranid frogs Evidence URLhttps://www.uniprot.org/uniprotkb/Q1MU21/entry
RECORD: Rec_0298595 VERIFIED: NO
Provenance & Taxonomy
Rana schmackeri,Odorrana schmackeri [Animal]; Odorrana hejiangensis [Animal]
Esculentin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0356777 VERIFIED: NO
Provenance & Taxonomy
Rana schmackeri [Animal]
Esculentin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID16427248 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16427248/
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