Peptide Database

Peptide NameChimeric CNP-K

Function Ontology

Natriuretic

Standard StatusStandard

Sequence Length35 amino acids

Chemical FormulaC166H271N55O46S3

DescriptionStandard

        CFGLKLDRIGSMSGLGCAGSVDHKGKQRKWDHPKR
    

Molecular Weight3869.46 Da

Isoelectric Point (pI)9.90

Net Charge (pH 7.0)4.91

Net Charge (pH 7.4) 4.57

Charge Density (pH 7.0) 0.1404

GRAVY Index-0.83

Hydrophobic Moment 0.45

Boman Index-0.21

Instability Index28.13

Aliphatic Index 55.71

Aromaticity 0.0571

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5625.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1648.56

LogP -18.35

H-bond Donors 61.0

H-bond Acceptors 56.0

Rotatable Bonds 134.0

Heavy Atoms 270.0

Ring Count 6.0

Amide Bonds 35.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0409846 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyNatriuretic peptide

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Disulfide1-17

Bio-Activity Profile

Function

Natriuretic

MethodCompetitive Radioimmunoassay

Half-LifeRat plasma (Intravenous), in vivo; 1081.8 s