Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length487 amino acids

Chemical FormulaC2439H3920N658O663S16

DescriptionStandard

        MARGPDNAPIWATLVVLASMGTAVTLATKPGIVARISQKGLDFACQQGVTVLQKQLQKIRVPDLSGRFKVKHIGKVHYSVYSITIVRFQLPSPQIRLQPGVGLKLSINSASVQVKGRCKARKRFIKASGKFDLSLDGISISADLKLGSDPTSGHITIACSSCSSHINSVHLRFKKSIVGWLIQLFRKKINSILREKINSQICKIVTKSVSSKLQPYIQTLPVTAKVDAVAGIDYHLVAPLTATADNLDGQLKGEFFRLAHRSPPPFSPPEMAFPPDHDRMVYMGISDYFFNTAGLVYYEAGVLKMTINNHMISRKSKFELTTKFLGTFLPEVARRFPNMKVQFLVSVSAPPYLTTRPSGFAFSPALEAQAFAVLPNSSLASLFLLGMVSWSTNASLKVGVQDSRLIGELNVGNRLALELKHSNIGFFPVKLLQDIMNYIVPIVVLPKVNEKLQRGFSLPMPAQIQLSNLRLLTQQNFLLLGADVHSF
    

Molecular Weight53582.26 Da

Isoelectric Point (pI)10.08

Net Charge (pH 7.0)30.41

Net Charge (pH 7.4) 29.47

Charge Density (pH 7.0) 0.0624

GRAVY Index0.13

Hydrophobic Moment 0.73

Boman Index0.11

Instability Index37.14

Aliphatic Index 103.08

Aromaticity 0.0821

Extinction Coeff. Reduced 31400.00

Extinction Coeff. Oxidized 31650.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0180621 VERIFIED: NO

Provenance & Taxonomy

OrganismCastor canadensis [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria