Peptide Database

Peptide NameCruzioseptin-1 (CZS-1)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Antimicrobial ▸ Antifungal

Antimicrobial ▸ Antifungal ▸ Anti-Candida

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length70 amino acids

Chemical FormulaC351H566N90O114S2

DescriptionStandard

        MAFLKKSLFLVLFLGLVSLSICEEEKREENEEEQDDDEQSEEKRGFLDIVKGVGKVALGAVSKLFGQEER
    

Molecular Weight7934.91 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-7.48

Net Charge (pH 7.4) -7.74

Charge Density (pH 7.0) -0.1068

GRAVY Index-0.35

Hydrophobic Moment 0.72

Boman Index-0.06

Instability Index62.24

Aliphatic Index 96.00

Aromaticity 0.0714

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3346.67

LogP -28.45

H-bond Donors 114.0

H-bond Acceptors 109.0

Rotatable Bonds 286.0

Heavy Atoms 557.0

Ring Count 5.0

Amide Bonds 73.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0184415 VERIFIED: YES

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyFrog skin active peptide (FSAP); Cruzioseptin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetEscherichia coli (Gram-negative)

RECORD: Rec_0225725 VERIFIED: NO

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyDermaseptin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0339421 VERIFIED: YES

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyFrog skin active peptide (FSAP); Cruzioseptin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetStaphylococcus aureus (Gram-positive)

RECORD: Rec_0366740 VERIFIED: YES

Provenance & Taxonomy

OrganismCruziohyla calcarifer [Animal]

FamilyFrog skin active peptide (FSAP); Cruzioseptin subfamily

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Defense peptide Antimicrobial Antibiotic Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic

TargetCandida albicans