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MYP_145775
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Basic Information
HRA2
Antimicrobial
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Standard
48 amino acids
C226H393N67O71
Standard
Sequence
AKTIRLESEVTAIKNALKKTNEAVSTLGNGVRVLATAVRELKDFVSKN
Physicochemical Analysis
5184.94 Da
9.99
3.80
3.60
0.0792
-0.17
0.76
-0.08
1.14
105.62
0.0208
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2293.54
-26.05
81.0
75.0
183.0
364.0
1.0
51.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0196047 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
LLC-MK2 cells
>9 μM
CC50 / cytotoxicity assay (no cytotoxicity at highest tested concentration)
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0210205 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Qualitative functional evidence
PaperPubMed PMID: 17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0283302 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-MPV Fusion inhibition
Human Metapneumovirus(hMPV) | LLC-MK2 cells
0.0021 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperIdentification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. | Deffrasnes C, Hamelin ME, Prince GA, Boivin G. | Antimicrob Agents Chemother. 2008 Jan;52(1):279-87. | DOI:10.1128/AAC.00793-07 | PMID:17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
RECORD: Rec_0331734 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0349375 VERIFIED: YES
Provenance & Taxonomy
Human metapneumovirus [Virus]
Virus-derived peptide
162145;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor Fusion inhibitor
Human metapneumovirus (Virus entry); LLC-MK2
0.0016 μM
Plaque assay
PaperIdentification and evaluation of a highly effective fusion inhibitor for human metapneumovirus. | Deffrasnes C, Hamelin ME, Prince GA, Boivin G. | Antimicrob Agents Chemother. 2008 | PMID:17967906 PMID17967906 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17967906/
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