Peptide Database

Peptide NameF2,5,12W

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC100H160N38O16

DescriptionStandard

        RWGRWLRKIRRWRPK
    

Molecular Weight2150.59 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)7.76

Net Charge (pH 7.4) 7.55

Charge Density (pH 7.0) 0.5172

GRAVY Index-2.08

Hydrophobic Moment 0.99

Boman Index-0.85

Instability Index183.41

Aliphatic Index 52.00

Aromaticity 0.2000

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 932.74

LogP -4.58

H-bond Donors 38.0

H-bond Acceptors 24.0

Rotatable Bonds 70.0

Heavy Atoms 154.0

Ring Count 7.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0145316 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0248906 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyCathelicidin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralityall-D amino-acid peptide [D]

C-TermAmidation

Other ModsD-Arg at D-Ala at 1st position, D-His at 9th position, D-Trp at D-Ala at 1st position, D-His at 9th position, D-Gly at 3rd position, D-Leu at 6th position, D-Ala at 1st position, D-His at 9th position

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Half-LifeHuman serum: Cyclization of F2,5,12W fur-ther improved the stability in serum; in the presence of serumthe peptide maintained its antibacterial activity up to 6 h

PaperMolhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ. Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization. Peptides. 2011 May;32(5):875-80 PMID:21376095 https://pubmed.ncbi.nlm.nih.gov/21376095/ PMID21376095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21376095/

RECORD: Rec_0261406 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hemolytic

Targethuman RBCs

Activity5.2 μg/mL

MethodLC50

RECORD: Rec_0323312 VERIFIED: NO

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0351632 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyDefensin

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

Activity8 μg/mL

MethodMIC

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