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MYP_145693
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Basic Information
F2,5,12W
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Anti-biofilm ▸ Biofilm inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
15 amino acids
C100H160N38O16
Standard
Sequence
RWGRWLRKIRRWRPK
Physicochemical Analysis
2150.59 Da
12.00
7.76
7.55
0.5172
-2.08
0.99
-0.85
183.41
52.00
0.2000
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
932.74
-4.58
38.0
24.0
70.0
154.0
7.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0035857 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiofilm Antibacterial
Staphylococcus epidermidis
2.5, 10, 2.5 μM
Crystal violet assay; Resazurin assay
RECORD: Rec_0043919 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
Human serum: peptide F2,5,12Wshowed a 2.5 times improved stability of antibacterial activity inthe presence of serum
PaperMolhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ. Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization. Peptides. 2011 May;32(5):875-80 PMID:21376095 https://pubmed.ncbi.nlm.nih.gov/21376095/ PMID21376095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21376095/
RECORD: Rec_0093013 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Bacillus subtilis
4 μg/mL
MIC
PMID33554385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33554385/
RECORD: Rec_0120339 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Cathelicidin
32630
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human serum: Sus-tained antibacterial activity up to 24 h was observed for peptideD-F2,5,12W
PaperMolhoek EM, van Dijk A, Veldhuizen EJ, Haagsman HP, Bikker FJ. Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization. Peptides. 2011 May;32(5):875-80 PMID:21376095 https://pubmed.ncbi.nlm.nih.gov/21376095/ PMID21376095 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21376095/
RECORD: Rec_0129541 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Defensin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
4 μg/mL
MIC
PMID33554385 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/33554385/
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