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MYP_145642
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Basic Information
Gramicidin S [Orn2,7K], GS [Orn2,7K]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
10 amino acids
C62H98N12O11
Standard
Sequence
VKLFPVKLFP
Physicochemical Analysis
1187.52 Da
10.00
1.73
1.52
0.1732
1.06
0.20
0.39
44.04
136.00
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
359.68
1.92
11.0
13.0
35.0
85.0
4.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0200578 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
The second and seventh residues of this cyclic peptide are Ornithines, an analog of lysine (one CH2 shorter). They are represented here with lysines. In addition, residue F is a D-amino acid. Even earlier reports are in Russian. Sergiev PG summarized some results on the peptide Science_direct. See also Biochem J. 1945;39(4):363-7. Pub-Med. Structure: Both X-ray and NMR have been used for stuctural studies (NMR+x)
Bio-Activity Profile
Antimicrobial Antifungal Spermicidal
E. cloacae
1.95-62.5 μg/mL
MIC
PaperGrammicidin S and its use in the treatment of infected wounds.
RECORD: Rec_0207993 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Hemolytic
sheep red blood cells
100 % hemolysis at 30 μM
Hemolysis
PMID22976321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22976321/
RECORD: Rec_0269237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa NBRC 3080
50.0 μg/mL
MIC
PMID22976321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22976321/
RECORD: Rec_0356421 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
The second and seventh residues of this cyclic peptide are Ornithines, an analog of lysine (one CH2 shorter). They are represented here with lysines. In addition, residue F is a D-amino acid. Even earlier reports are in Russian. Sergiev PG summarized some results on the peptide Science_direct. See also Biochem J. 1945;39(4):363-7. Pub-Med. Structure: Both X-ray and NMR have been used for stuctural studies (NMR+x)
Bio-Activity Profile
Antimicrobial Antifungal Spermicidal
15 Klebsiella pneumoniae
7.8-62.5 μg/mL
MIC
PaperGrammicidin S and its use in the treatment of infected wounds.
RECORD: Rec_0363345 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Bacillus megaterium ATCC 19213
6.25 μg/mL
MIC
PMID22976321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22976321/
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