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MYP_145642
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Basic Information
Gramicidin S [Orn2,7K], GS [Orn2,7K]
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
10 amino acids
C62H98N12O11
Standard
Sequence
VKLFPVKLFP
Physicochemical Analysis
1187.52 Da
10.00
1.73
1.52
0.1732
1.06
0.20
0.39
44.04
136.00
0.2000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
359.68
1.92
11.0
13.0
35.0
85.0
4.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0017788 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Bacteriocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli NBRC 12734
50.0 μg/mL
MIC
PMID22976321 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22976321/
RECORD: Rec_0032038 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0033259 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]; Bacteria [Bacterium]
2; 2
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID23736764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23736764/
RECORD: Rec_0055582 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
The second and seventh residues of this cyclic peptide are Ornithines, an analog of lysine (one CH2 shorter). They are represented here with lysines. In addition, residue F is a D-amino acid. Even earlier reports are in Russian. Sergiev PG summarized some results on the peptide Science_direct. See also Biochem J. 1945;39(4):363-7. Pub-Med. Structure: Both X-ray and NMR have been used for stuctural studies (NMR+x)
Bio-Activity Profile
Antimicrobial Antifungal Spermicidal
15 strains E. faecium
3.9 μg/mL
MIC
PaperGrammicidin S and its use in the treatment of infected wounds.
RECORD: Rec_0079099 VERIFIED: YES
Provenance & Taxonomy
Bacillus brevis [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
The second and seventh residues of this cyclic peptide are Ornithines, an analog of lysine (one CH2 shorter). They are represented here with lysines. In addition, residue F is a D-amino acid. Even earlier reports are in Russian. Sergiev PG summarized some results on the peptide Science_direct. See also Biochem J. 1945;39(4):363-7. Pub-Med. Structure: Both X-ray and NMR have been used for stuctural studies (NMR+x)
Bio-Activity Profile
Antimicrobial Antifungal Spermicidal
15 Acinetobacter baumannii
31.2-62.5 μg/mL
MIC
PaperGrammicidin S and its use in the treatment of infected wounds.
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