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MYP_145604
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Basic Information
Wollamide B [l3D-Phe(4Cl)]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
6 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
WLXVNX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0077336 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
x(3)=D-4-Cl-Phe; x(6)=D-Orn
Bio-Activity Profile
Antimicrobial Anticancer
HepG2
60 μM
IC50
PaperPubMed PMID: 28423019 PMID28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423019/
RECORD: Rec_0103182 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
x(3)=D-4-Cl-Phe; x(6)=D-Orn
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperPubMed PMID: 28423019 PMID28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423019/
RECORD: Rec_0149145 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 3,6
Bio-Activity Profile
Antimicrobial Antibacterial
Human hepatocellular carcinoma HepG2
60 μM
IC50
PMID28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423019/
RECORD: Rec_0274949 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
unspecified non-canonical residue at 3,6
Bio-Activity Profile
Antimicrobial Antibacterial
Mycobacterium tuberculosis H37Rv
1.9 μM
MIC
PMID28423019 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28423019/
RECORD: Rec_0294919 VERIFIED: NO
Provenance & Taxonomy
Streptomyces nov. sp. [Bacterium]
Structure & Mods
backbone-cyclized peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
L3: D-Leucine; K6: D-Ornithine
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus; Bacillus subtilis
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