Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length251 amino acids

Chemical FormulaC1286H1975N345O366S8

DescriptionStandard

        MNHPRHQPYSLERNRQPSRHLGLTSSLVGTLEAAVSFCLQGEFFSRNRNSSVPFDAPPIRLPQKHDHMIYFAVSEYAFNTASRVYHQAGQMKFTIQNKHLARLYPNMELELETSPESAPFLTFTPGNVTFMPVMDIQAFALLPKSAGRKPLFQIKASTNISITINGNSSRITGSLATGSELKLELKHSNIGFFNVNLMESIFNYYAFHIIYPSLNAKLEEGIPLPLPRDTYLNSLEFQIHENFLFLGANVD
    

Molecular Weight28381.05 Da

Isoelectric Point (pI)7.92

Net Charge (pH 7.0)1.40

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0056

GRAVY Index-0.22

Hydrophobic Moment 0.59

Boman Index0.07

Instability Index44.23

Aliphatic Index 83.98

Aromaticity 0.1116

Extinction Coeff. Reduced 13410.00

Extinction Coeff. Oxidized 13410.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0397183 VERIFIED: NO

Provenance & Taxonomy

OrganismCervus elaphus hippelaphus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence