Peptide Database

Peptide NameCanakinumab

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Standard StatusStandard

Sequence Length448 amino acids

Chemical FormulaC2196H3398N588O669S16

DescriptionStandard

        QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPGKGLEWVAIIWYDGDNQYYADSVKGRFTISRDNSKNTLYLQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
    

Molecular Weight49253.05 Da

Isoelectric Point (pI)8.49

Net Charge (pH 7.0)5.47

Net Charge (pH 7.4) 4.52

Charge Density (pH 7.0) 0.0122

GRAVY Index-0.40

Hydrophobic Moment 0.54

Boman Index0.01

Instability Index44.58

Aliphatic Index 71.03

Aromaticity 0.0960

Extinction Coeff. Reduced 79300.00

Extinction Coeff. Oxidized 79925.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0010268 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Mus musculus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10090

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsGlycosylation

Bio-Activity Profile

Function

Immunomodulatory

Half-Life26 days

RECORD: Rec_0278214 VERIFIED: NO