Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length461 amino acids

Chemical FormulaC2360H3683N589O677S17

DescriptionStandard

        METRQILTVWGFFLLWNLLTASSITSLNQPGIKVRITQKALDYGVQAGMGILEKLIKKKRIPDFKGSETLDFLKVEYIDYNFSNIRFSAFSFPNTSLILVPGTGIKALTNHGSANISTDWEIKSPLFKDEGGASLFLSEVFFTGIINLSRSAMGHPTMKLEDCYVHISHAHIAFSGELSPLYNSFSEPMEKPILKNLNEKLCPIIKDEMERINAELRTLDVLTRIDENTLLDYSLINSPEIQESAIDMDLKGTFYLMENFTDPPFRPAPFTLPDLNDFMVYIGISEYFFRSASFAYFTAGVFNITLTTKEISKHFPQNSKNFGRVISQIAEIYLNTEPFIAMVVVTSPPAVNLQPGNFTVEIPGSIKMFTQPENSTAETILSMNFVASTSVDLVILGQKLICSLSLNRARPLIQLFPLFQMLRFENILSSVLHFGLIPLANGKSVAETLKRAFEHSGNSMV
    

Molecular Weight51684.13 Da

Isoelectric Point (pI)5.71

Net Charge (pH 7.0)-6.77

Net Charge (pH 7.4) -7.54

Charge Density (pH 7.0) -0.0147

GRAVY Index0.09

Hydrophobic Moment 0.81

Boman Index0.15

Instability Index34.14

Aliphatic Index 97.94

Aromaticity 0.1063

Extinction Coeff. Reduced 32890.00

Extinction Coeff. Oxidized 33015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0386933 VERIFIED: NO

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence