Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length141 amino acids

Chemical FormulaC693H1132N194O186S3

DescriptionStandard

        PVLLPAAREPMLLLAVTDFVANSAAFVYFTAGALRWTVTGSMLPRRFPLRLRTKSLGLFSPRLQELYPDQPVELRLSARRQPLLSCRPNGLRLALFGSAEAVVVLPNATRVSAFLLDIDANVTGKPLLTANRIGGSVSLVG
    

Molecular Weight15253.78 Da

Isoelectric Point (pI)11.27

Net Charge (pH 7.0)7.96

Net Charge (pH 7.4) 7.87

Charge Density (pH 7.0) 0.0565

GRAVY Index0.36

Hydrophobic Moment 0.52

Boman Index0.13

Instability Index45.50

Aliphatic Index 115.53

Aromaticity 0.0709

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6008.79

LogP -53.72

H-bond Donors 213.0

H-bond Acceptors 197.0

Rotatable Bonds 487.0

Heavy Atoms 1076.0

Ring Count 23.0

Amide Bonds 148.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0307746 VERIFIED: NO

Provenance & Taxonomy

OrganismDromaius novaehollandiae [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria