Peptide Database

Peptide NameRamucirumab

Function Ontology

Anticancer

Anticancer ▸ Anti-angiogenic activity ▸ VEGFR targeting ▸ Anti-VEGFR2 cross

Enzyme modulation ▸ Receptor tyrosine kinase inhibition ▸ VEGFR inhibition cross

Enzyme modulation ▸ Receptor tyrosine kinase inhibition ▸ VEGFR inhibition ▸ Anti-VEGFR2 cross

Wound healing/Regeneration ▸ Angiogenesis modulation ▸ Anti-angiogenic

Standard StatusStandard

Sequence Length60 amino acids

Chemical FormulaC285H434N74O88S2

DescriptionStandard

        EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYSMNWVRQAPGKGLEWVSSISSSSSYIYY
    

Molecular Weight6369.07 Da

Isoelectric Point (pI)9.00

Net Charge (pH 7.0)1.82

Net Charge (pH 7.4) 1.63

Charge Density (pH 7.0) 0.0304

GRAVY Index0.02

Hydrophobic Moment 0.48

Boman Index0.17

Instability Index50.13

Aliphatic Index 74.67

Aromaticity 0.1333

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 16960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2601.39

LogP -31.40

H-bond Donors 95.0

H-bond Acceptors 92.0

Rotatable Bonds 204.0

Heavy Atoms 449.0

Ring Count 12.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0245259 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMonoclonal antibody

Tax ID9606

Structure & Mods

Configlinear multidomain protein biologic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-angiogenic Anticancer Monoclonal antibody Anti-VEGFR2

Half-Life15 d

PaperPubMed-linked source references: PMID:28285368; PMID:28277882; PMID:28276858; PMID:28260227; PMID:28220199; PMID:28220020; PMID:28212372; PMID:28203696; PMID:28203161 PMID28285368;28277882;28276858;28260227;28220199;28220020;28212372;28203696;28203161 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28285368/ PatentUS2013067098