Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length245 amino acids

Chemical FormulaC1272H1924N282O362S8

DescriptionStandard

        IDDLAEVDYSLNSLPAVFRPFIDLNLKGIVYPAGNYIGPPYVAAPFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITIAEEVKSGKLICFLFFFFFLQTCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATEIPIISLEQDSFTVEIQGSMEVFAVLPDSTTQSLFTMNIAANTSLALNIFDQKLIGSLCLNRLQFSLAHSNVGFFEISLLENILSYILQTEVIPSANAKLSKGFPLP
    

Molecular Weight27215.07 Da

Isoelectric Point (pI)4.30

Net Charge (pH 7.0)-12.16

Net Charge (pH 7.4) -12.51

Charge Density (pH 7.0) -0.0496

GRAVY Index0.47

Hydrophobic Moment 0.60

Boman Index0.29

Instability Index45.67

Aliphatic Index 104.33

Aromaticity 0.1469

Extinction Coeff. Reduced 17880.00

Extinction Coeff. Oxidized 18005.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178655 VERIFIED: NO

Provenance & Taxonomy

OrganismCathartes aura [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria