Peptide Database

Peptide NameSutimlimab

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length445 amino acids

Chemical FormulaC2171H3353N573O672S17

DescriptionStandard

        EVQLVESGGGLVKPGGSLRLSCAASGFTFSNYAMSWVRQAPGKGLEWVATISSGGSHTYYLDSVKGRFTISRDNSKNTLYLQMNSLRAEDTALYYCARLFTGYAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
    

Molecular Weight48777.39 Da

Isoelectric Point (pI)7.66

Net Charge (pH 7.0)1.46

Net Charge (pH 7.4) 0.60

Charge Density (pH 7.0) 0.0033

GRAVY Index-0.36

Hydrophobic Moment 0.55

Boman Index0.02

Instability Index46.14

Aliphatic Index 69.33

Aromaticity 0.0989

Extinction Coeff. Reduced 73800.00

Extinction Coeff. Oxidized 74425.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0114138 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyMonoclonal antibody

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Enzyme replacement

Half-Life,At the approved recommended dosage, the terminal elimination half-life of sutimlimab is 21 days.