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MYP_145355
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Basic Information
N-Ac-VIRIP-amide
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
20 amino acids
C112H171N23O27S
Standard
Sequence
LEAIPMSIPPEVKFNKPFVF
Physicochemical Analysis
2303.76 Da
6.14
-0.24
-0.45
-0.0118
0.39
0.30
0.29
59.40
92.50
0.1500
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
771.02
-1.56
23.0
28.0
69.0
163.0
7.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0038670 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of virus infection in P4-CCR5 cells
100 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0044732 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0085151 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of virus infection in P4-CCR5 cells
14.79±2.56 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0093433 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
VIRIP
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
P4-CCR5
14.79±2.56 μM
IC50
PaperDiscovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide. PMID17448989 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17448989/
RECORD: Rec_0126133 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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