Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2392H3749N617O691S17

DescriptionStandard

        MHITNLGLPASSLGLVPGSGLSLSISDAFISLNGHWHVKYLKFIKDSGSFDLTVSGLTISVTMGVNSDETGRPTVSSSNCAASVGHVSIEFHGGASWLYNLFSSFIENALRSAIQNQICPLVHDAISDINPHLKTMNVLAQVDKYAEIEYSLVTSPVVSNTFIQFSLKGEFYKIGQHQEPPFSAPPFSLPQTNGSMLYLGLSSFIANSAGFVYHNAGVLGLYVTDDMIPSSSPLRLNTKTFGAFIPEIAKRFPNMMMKLLVKTLEPPRITFEPNNVTLQANGTVTAYAILPNNTLEALFILNLVSLDGQGEQFICSKGRPITEQIISMTLGTSYVGQFQVMPLNNIFTMILKVVVIPKVNEKLQQGYPLPAISHMNLVNTQLKVLKDQLVAPNEVVVDPRRLFPENSYELLQAALFHLSRDVVMETRFPEVATVTESHLPHAVGKKEAHAVAHFLHQGEGLLVILFCLPAEPHDEVTTKTHP
    

Molecular Weight52751.18 Da

Isoelectric Point (pI)6.12

Net Charge (pH 7.0)-6.92

Net Charge (pH 7.4) -8.20

Charge Density (pH 7.0) -0.0144

GRAVY Index0.14

Hydrophobic Moment 0.70

Boman Index0.18

Instability Index38.62

Aliphatic Index 100.48

Aromaticity 0.0830

Extinction Coeff. Reduced 28880.00

Extinction Coeff. Oxidized 29130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0000677 VERIFIED: NO

Provenance & Taxonomy

OrganismScleropages formosus [Animal]

FamilyBPI/LBP

Tax ID113540

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria