Peptide Database

Peptide NameTemporin-Las

Function Ontology

Anticancer

Antimicrobial

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length13 amino acids

Chemical FormulaC76H132N20O16

DescriptionStandard

        LLRHVVKILSKYL
    

Molecular Weight1581.99 Da

Isoelectric Point (pI)10.29

Net Charge (pH 7.0)2.84

Net Charge (pH 7.4) 2.59

Charge Density (pH 7.0) 0.2188

GRAVY Index0.81

Hydrophobic Moment 0.79

Boman Index0.15

Instability Index44.93

Aliphatic Index 194.62

Aromaticity 0.0769

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 595.60

LogP -0.81

H-bond Donors 22.0

H-bond Acceptors 20.0

Rotatable Bonds 54.0

Heavy Atoms 112.0

Ring Count 2.0

Amide Bonds 12.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0143750 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTemporin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

Targetrabbit erythrocytes; human erythrocytes

MethodHemolysis assay (250 μg/mL peptide exposure)

RECORD: Rec_0144981 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTemporin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetHL-7702 (L-02)

Activity37.00 %

MethodCell proliferation inhibition assay (50 μg/mL peptide exposure)

RECORD: Rec_0202261 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTemporins

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anticancer

TargetHeLa (cervical cancer)

MethodCell proliferation inhibition assay (50 μg/mL peptide exposure)

PaperDesigned synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain | https://pubmed.ncbi.nlm.nih.gov/22641352/ PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/

RECORD: Rec_0206075 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTemporin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anticancer

TargetSMMC-7721

MethodCell proliferation inhibition assay (50 μg/mL peptide exposure)

RECORD: Rec_0209186 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyTemporins

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Anticancer

TargetBGC-823 (gastric cancer)

MethodCell proliferation inhibition assay (50 μg/mL peptide exposure)

PaperDesigned synthetic analogs of the α-helical peptide temporin-La with improved antitumor efficacies via charge modification and incorporation of the integrin αvβ3 homing domain | https://pubmed.ncbi.nlm.nih.gov/22641352/ PMID22641352 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22641352/

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