Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2432H3893N639O667S17

DescriptionStandard

        MARGPDDTWRWATLVMLAALGTAVTATTNPGVVARITQKGLDYACQQGVATLQKELEKITIPTLSGSFKVKHLGKGKYSFYSLVIHGFKLPNSQIRPLPNQGLDLSIKDASIKMSGKWKARKSFIKVSGKFDLSVEGISILAALKLGYDPTSGHATVACSSCRSHINSVRVRISRSSLGWLIQLFHKKIESSLRNSMNRKICEVVTSAVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADSLDGLLKGEFFRLAHRRPPPFAPPALTLPTDHNRMVYLGISEYLFNTAGLVYQEAGVLNLTLSNDMLPKKSKFFLTTKFFGTLLPQVAKMFPDMKMQLLIWAPSPPNVAVCPTGLDLTFSLDTQAVAVLPDSSLAPLFLLEMNMNISVDIRARSNRLVGELKLDKLLLKLKHSDIDHFPVELLQNVMNYVVPTVVIPKINKKLQKGFPLPLPASIQLFNLVFQPHQDFLLFGADVRYG
    

Molecular Weight53300.91 Da

Isoelectric Point (pI)9.73

Net Charge (pH 7.0)22.33

Net Charge (pH 7.4) 21.43

Charge Density (pH 7.0) 0.0462

GRAVY Index0.07

Hydrophobic Moment 0.69

Boman Index0.11

Instability Index37.28

Aliphatic Index 102.13

Aromaticity 0.0828

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44140.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0172968 VERIFIED: NO

Provenance & Taxonomy

OrganismBalaenoptera acutorostrata scammoni [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence