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MYP_144913
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Basic Information
Api793
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
20 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XWXWXRPVYXPRPRPPHPRL
Physicochemical Analysis
0.00 Da
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0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0309497 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
7460
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
gu = N
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli ATCC 25922
8 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0372848 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa(DSM 1117) (50% MHB)
16 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0374736 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa(DSM 9644)
8 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0385131 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa(DSM 3227)
16 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0410359 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli (ATCC 25922 )
8 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
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