Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length482 amino acids

Chemical FormulaC2354H3767N615O706S30

DescriptionStandard

        MVMSWFCSAVLLILSALCLCSAENPGVKVKLTKMIMDKGAAYAKQNLISQLKDKPLPDVNGTITMGEENMNYAFLNIRLVDFNYTSLSSSFVPGTGIKLVIKGGTTTLTSDFELYGWLLTDNGFCMLNLTEICITVIIGVQRDKSNKPSIHTVSCEADILGVNLTMIGGVSYIYDAIRKPMIKMIRNDLNQQVCSMLRGQIQQWDQTLNDLKLNILLDNSIGVDLSLVNDPVFTEQNAEIDSECMFYSPVNETKVALTPAAMSFDAQKGSMLTVGLSEASFNSASQVYHSGGGFIFRLFDAHSKSNSKAAALLAGLCQPFGKTKKQLVLLSASKAPTFLLQTNNVTVGFSGIINAHALLPRAQRETLFTARTDICFSAQVSILDSNFLPGLNLTGSISLNSFNLHVEQEQSEAKKREAEIKAIFMEEILRMLNDNLQTGLYIPFRFFKITTSTIKKGFMMVNANMNFECLENVLSSGNPSKS
    

Molecular Weight52941.74 Da

Isoelectric Point (pI)6.54

Net Charge (pH 7.0)-1.13

Net Charge (pH 7.4) -1.86

Charge Density (pH 7.0) -0.0023

GRAVY Index0.11

Hydrophobic Moment 0.75

Boman Index0.13

Instability Index35.91

Aliphatic Index 97.12

Aromaticity 0.0788

Extinction Coeff. Reduced 29910.00

Extinction Coeff. Oxidized 30535.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0418022 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptobrachium leishanense [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence