‹ ›
MYP_144797
← PREVIOUS NEXT → BACK
Basic Information
Api796 apidaecin petide derivative
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
22 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XIXIXIXRPVYXPRPRPPHPRL
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0267147 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa(DSM 9644)
16 μg/mL
MIC
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0305441 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
7460
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
gu = N
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 3227
16 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0362119 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Tetramethylguanidino
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 1117 (50% MHB)
8 μg/mL
MIC
Mouse serum: Half-life time (mouse serum )=249 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0400884 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Tetramethylguanidino
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 9644 (50% MHB)
16 μg/mL
MIC
Mouse serum: Half-life time (mouse serum )=249 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0417899 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Tetramethylguanidino
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 3227 (50% MHB)
16 μg/mL
MIC
Mouse serum: Half-life time (mouse serum )=249 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
FIRST PREV 1 ... 3 4 5
Showing 5 records · Page 5 of 5