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MYP_144797
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Basic Information
Api796 apidaecin petide derivative
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxicity
not Standard
22 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XIXIXIXRPVYXPRPRPPHPRL
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0018536 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Pseudomonas aeruginosa DSM 1117/3227/9644; Escherichia coli ATCC 25922; Klebsiella pneumoniae DSM 681; human cell safety panel
MIC; IC50; Hemolysis
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0022699 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
7460
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
gu = N
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 1117
8 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0037835 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
7460
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
gu = N
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae DSM 681
16 μg/mL
MIC
PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0044558 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Apidaecin
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Tetramethylguanidino
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa DSM 1117 (100% MHB)
64 μg/mL
MIC
Mouse serum: Half-life time (mouse serum )=249 min
PaperBluhm ME, Schneider VA, Schäfer I, Piantavigna S, Goldbach T, Knappe D, Seibel P, Martin LL, Veldhuizen EJ, Hoffmann R. N-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa Front Cell Dev Biol. 2016 May 10;4:39 PMID:27243004 https://pubmed.ncbi.nlm.nih.gov/27243004/ PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
RECORD: Rec_0047097 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
L-amino acids with non-proteinogenic L-ornithine [Mixed]
Guanidation (Orn1 conjugated with N,N,N′,N′-tetramethylguanidino)
Free carboxyl (OH)
Contains non-proteinogenic L-ornithine (O/X notation)
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
cells(IC50>0.6g/L)
Qualitative functional evidence
PaperN-Terminal Ile-Orn- and Trp-Orn-Motif Repeats Enhance Membrane Interaction and Increase the Antimicrobial Activity of Apidaecins against Pseudomonas aeruginosa. Front Cell Dev Biol. 2016 May 10;4:39. doi: 10.3389/fcell.2016.00039. PMID: 27243004. PMID27243004 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27243004/
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