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MYP_144764
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Basic Information
Varv peptide A (Varv A; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C116H185N35O40S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
2902.31 Da
5.96
-0.30
-0.59
-0.0102
0.15
0.26
0.15
46.59
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.65
46.0
46.0
84.0
197.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0321034 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola hederacea [Plant]; Viola biflora [Plant]; Viola odorata [Plant]; Viola tricolor [Plant]
Cyclic Peptide
97441, 214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Nematocidal Anthelmintic Hemolytic Antiviral Anti-HIV Anticancer Antimicrobial
Trichostrongylus colubriformis
PaperPubMed PMID 1532834 | PubMed PMID 7168722 | PubMed PMID 7000000 PMID1532834;7168722;7000000;15328347;16872;27000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1532834/
RECORD: Rec_0328471 VERIFIED: NO
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
97415
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
noncanonical stereochemical modification [Modified]
disulfide-stabilized; exact pairings not extracted
cystine-knot scaffold
Bio-Activity Profile
Anticancer Antimicrobial
PaperPlant Antimicrobial Oligopeptides with Anticancer Properties as a Source of Biologically Active Peptides—An In Silico Study PMID41009751 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/41009751/
RECORD: Rec_0336707 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer
CCRF-CEM
3.56 μM
IC50
PaperPubMed PMID: 20580652 | PubMed PMID: 14987049 | PubMed PMID: 12477048 PMID20580652;14987049;12477048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0350261 VERIFIED: YES
Provenance & Taxonomy
Viola odorata L. and Viola tricolor L [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli
160 μM
MIC
PMID28669767 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28669767/
RECORD: Rec_0360654 VERIFIED: NO
Provenance & Taxonomy
Viola arvensis [Plant]; Viola hederaceae [Plant]; Viola biflora [Plant]; Viola odorata [Plant]; Viola tricolor [Plant]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-26
Bio-Activity Profile
Antimicrobial
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