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MYP_144764
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Basic Information
Varv peptide A (Varv A; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C116H185N35O40S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
2902.31 Da
5.96
-0.30
-0.59
-0.0102
0.15
0.26
0.15
46.59
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.65
46.0
46.0
84.0
197.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0207913 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]; Viola hederacea [Plant]; Viola biflora [Plant]; Viola odorata [Plant]; Viola tricolor [Plant]
Cyclic Peptide
97441, 214053
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Cytotoxic Nematocidal Anthelmintic Hemolytic Antiviral Anti-HIV Anticancer Antimicrobial
U251 cell line
37.18 μg/mL
IC50
PaperPubMed PMID 1532834 | PubMed PMID 7168722 | PubMed PMID 7000000 PMID1532834;7168722;7000000;15328347;16872;27000 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1532834/
RECORD: Rec_0219365 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Pseudomonas aeruginosa
80 μM
MIC
PaperFractionation Protocol for the Isolation of Polypeptides from Plant Biomass
RECORD: Rec_0219880 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Escherichia coli
>160 μM
MIC
PaperFractionation Protocol for the Isolation of Polypeptides from Plant Biomass
RECORD: Rec_0243937 VERIFIED: NO
Provenance & Taxonomy
Insecta [Animal]
50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0253225 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
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