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MYP_144764
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Basic Information
Varv peptide A (Varv A; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C116H185N35O40S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
2902.31 Da
5.96
-0.30
-0.59
-0.0102
0.15
0.26
0.15
46.59
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.65
46.0
46.0
84.0
197.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0131672 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer
RPMI-8226/Dox40
2.73 μM
IC50
PaperPubMed PMID: 20580652 | PubMed PMID: 14987049 | PubMed PMID: 12477048 PMID20580652;14987049;12477048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0132539 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Fusarium culmorum
40 μM
MIC
PaperFractionation Protocol for the Isolation of Polypeptides from Plant Biomass
RECORD: Rec_0141777 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
C. utrechtense
6.25 μM
MIC
PaperFractionation Protocol for the Isolation of Polypeptides from Plant Biomass
RECORD: Rec_0160349 VERIFIED: YES
Provenance & Taxonomy
Viola odorata [Plant]
97441
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
A. alternatam
1.5 μM
MIC
PaperFractionation Protocol for the Isolation of Polypeptides from Plant Biomass
RECORD: Rec_0164859 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Varv peptide
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
Fibrosarcoma (cell line not reported)
PaperCancerPPD2 curated year-page record; primary PMID 9548831 (1998), additional curated PMID 18957441. PMID9548831;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9548831/
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