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MYP_144764
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Basic Information
Varv peptide A (Varv A; Plant defensin)
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
29 amino acids
C116H185N35O40S6
Standard
Sequence
GLPVCGETCVGGTCNTPGCSCSWPVCTRN
Physicochemical Analysis
2902.31 Da
5.96
-0.30
-0.59
-0.0102
0.15
0.26
0.15
46.59
43.45
0.0345
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1174.30
-18.65
46.0
46.0
84.0
197.0
5.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0076648 VERIFIED: YES
Provenance & Taxonomy
Viola arvensis [Plant]
Defensin
Structure & Mods
side-chain cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
5-19; 9-21; 14-26
Bio-Activity Profile
Anticancer
Human tumor cell lines: RPMI-8226/s
3.24 μM
IC50
PaperPubMed PMID: 20580652 | PubMed PMID: 14987049 | PubMed PMID: 12477048 PMID20580652;14987049;12477048 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20580652/
RECORD: Rec_0087830 VERIFIED: NO
Provenance & Taxonomy
Viola arvensis [Plant]
Cyclotide
Structure & Mods
backbone-cyclized cyclotide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PaperVarv peptide A Evidence URLhttps://www.uniprot.org/uniprotkb/P58446/entry
RECORD: Rec_0095688 VERIFIED: NO
Provenance & Taxonomy
Viola tricolor [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0100635 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 37.9%, E 0.0%, T 27.6%, C 34.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0111526 VERIFIED: YES
Provenance & Taxonomy
Viola biflora [Plant]
Viola arvensis,Viola odorata, Viola tricolor, Viola baoshanensis, Viola yedoensis, and Viola biflora
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Anticancer
Fibrosarcoma (Fibrous connective tissue)
PMID9548831;18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9548831/
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