Peptide Database

Peptide NameCholecystokinin

Function Ontology

Gastrointestinal bioactivity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuromuscular and muscle activity ▸ Myotropic activity

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Standard StatusStandard

Sequence Length95 amino acids

Chemical FormulaC469H756N150O143S3

DescriptionStandard

        QPVVPAEATDPVEQRAQEAPRRQLRAVLRTDGEPRARLGALLARYIQQVRKAPSGRMSVLKNLQSLDPSHRISDRDYMGWMDFGRRSAEDYEYPS
    

Molecular Weight10880.13 Da

Isoelectric Point (pI)9.68

Net Charge (pH 7.0)2.87

Net Charge (pH 7.4) 2.59

Charge Density (pH 7.0) 0.0302

GRAVY Index-0.89

Hydrophobic Moment 0.81

Boman Index-0.27

Instability Index77.33

Aliphatic Index 69.89

Aromaticity 0.0632

Extinction Coeff. Reduced 11460.00

Extinction Coeff. Oxidized 11460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4784.12

LogP -52.35

H-bond Donors 168.0

H-bond Acceptors 150.0

Rotatable Bonds 358.0

Heavy Atoms 765.0

Ring Count 16.0

Amide Bonds 102.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0014170 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyCholecystokinin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods77:Sulfotyrosine; 83:Phenylalanine amide; 91:Sulfotyrosine; 93:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0093557 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0104409 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyCholecystokinin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

Other Mods77:Sulfotyrosine; 83:Phenylalanine amide; 91:Sulfotyrosine; 93:Sulfotyrosine

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Myotropic Receptor modulation

TargetCCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion

Half-LifeMammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour

RECORD: Rec_0284328 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyGastrin/cholecystokinin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsTyr77 Sulfotyrosine; Phe83 Amidation; Tyr91 Sulfotyrosine; Tyr93 Sulfotyrosine

Bio-Activity Profile

Function

Hormone Gastrointestinal Neuropeptide