Peptide Database

Peptide NameCircular bacteriocin; circularin A uberolysin family

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length98 amino acids

Chemical FormulaC460H760N114O125S5

DescriptionStandard

        MKSKRMEFHNKFLIVSAMLAVISWLSLGVVSFPMLAGTLGISTGSAATVVNLISAYSTVTAVISIVGAITGVGSIGSGIAATVLYMLKKKSAAKAALW
    

Molecular Weight10047.97 Da

Isoelectric Point (pI)10.30

Net Charge (pH 7.0)6.58

Net Charge (pH 7.4) 6.30

Charge Density (pH 7.0) 0.0672

GRAVY Index0.99

Hydrophobic Moment 0.42

Boman Index0.39

Instability Index17.02

Aliphatic Index 122.45

Aromaticity 0.0714

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3750.07

LogP -32.87

H-bond Donors 136.0

H-bond Acceptors 138.0

Rotatable Bonds 333.0

Heavy Atoms 704.0

Ring Count 11.0

Amide Bonds 99.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0040417 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus mitis [Bacterium]

FamilyCircular bacteriocin

Structure & Mods

Confighead-to-tail cyclic bacteriocin scaffold [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Non-hemolytic Non-ribosomal