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MYP_144625
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Basic Information
Cycloviolacin H3
Antimicrobial
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Antiviral
Antiviral ▸ Anti-HIV
Standard
30 amino acids
C129H198N36O41S6
Standard
Sequence
GLPVCGETCFGGTCNTPGCICDPWPVCTRN
Physicochemical Analysis
3101.56 Da
4.37
-1.30
-1.59
-0.0432
0.13
0.45
0.18
45.31
45.33
0.0667
5500.00
5875.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1191.45
-15.53
45.0
46.0
88.0
212.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0011957 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antiviral Nematocidal Anthelmintic
Haemonchus contortus
PMID15824119;18618890 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0055629 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
HIV
PaperPubMed PMID: 10600388 PMID10600388 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10600388/
RECORD: Rec_0075388 VERIFIED: YES
Provenance & Taxonomy
Australia violet [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0090121 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0192659 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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