Peptide Database

Peptide NameLinaclotide

Function Ontology

Guanylate cyclase-C agonist Gastrointestinal secretagogue

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC59H85N15O21S6

DescriptionStandard

        CCEYCCNPACTGCY
    

Molecular Weight1532.78 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.30

Net Charge (pH 7.4) -1.59

Charge Density (pH 7.0) -0.0927

GRAVY Index0.32

Hydrophobic Moment 0.24

Boman Index0.14

Instability Index69.59

Aliphatic Index 7.14

Aromaticity 0.1429

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 573.91

LogP -7.55

H-bond Donors 25.0

H-bond Acceptors 26.0

Rotatable Bonds 42.0

Heavy Atoms 101.0

Ring Count 3.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0112855 VERIFIED: YES

Provenance & Taxonomy

OrganismEscherichia coli [Bacterium]; Homo sapiens [Animal]; synthetic construct [Synthetic]

FamilyPeptide/peptidomimetic

Tax ID562;9606;32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide1-6, 2-10, 5-13

Bio-Activity Profile

Function

Guanylate cyclase-C agonist Gastrointestinal secretagogue

TargetGuanylate cyclase-C on intestinal epithelium

Half-LifeClinical/Human: Can't be calculated because not sistemically absorbed