Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length98 amino acids

Chemical FormulaC494H781N125O135S5

DescriptionStandard

        IPKGSPLHLNTSQFGVFIPQLRTLYPDMKMQVLLYASDMPLFSFTSGLMNIHVKMAAKFSAVKADDALVPLFTLNVDSRFSGIAQISNQKLTGAFKVN
    

Molecular Weight10791.57 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)3.93

Net Charge (pH 7.4) 3.61

Charge Density (pH 7.0) 0.0401

GRAVY Index0.24

Hydrophobic Moment 0.40

Boman Index0.18

Instability Index32.97

Aliphatic Index 96.53

Aromaticity 0.1020

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4137.66

LogP -35.97

H-bond Donors 139.0

H-bond Acceptors 146.0

Rotatable Bonds 354.0

Heavy Atoms 759.0

Ring Count 18.0

Amide Bonds 107.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0368042 VERIFIED: YES

Provenance & Taxonomy

OrganismDanio rerio [Animal]

FamilyBPI/LBP

Tax ID7955

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria