Peptide Database

Peptide NamePhoratoxin F

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC202H334N64O64S6

DescriptionStandard

        KSCCPTTTARNIYNTCRLAGGSRPICAKLSGCKIISGTKCDSGWDH
    

Molecular Weight4875.59 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)4.79

Net Charge (pH 7.4) 4.44

Charge Density (pH 7.0) 0.1040

GRAVY Index-0.33

Hydrophobic Moment 0.66

Boman Index-0.08

Instability Index48.02

Aliphatic Index 57.39

Aromaticity 0.0435

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2072.80

LogP -29.19

H-bond Donors 81.0

H-bond Acceptors 76.0

Rotatable Bonds 159.0

Heavy Atoms 336.0

Ring Count 6.0

Amide Bonds 47.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0083030 VERIFIED: NO

Provenance & Taxonomy

OrganismPhoradendron tomentosum [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin

RECORD: Rec_0236817 VERIFIED: YES

Provenance & Taxonomy

OrganismPhoradendron tomentosum [Plant]

FamilyThionin

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidemultiple disulfide bonds reported, sites not specified

Bio-Activity Profile

Function

Anticancer Cytotoxic Toxin

Target10 cancer cell lines

Activity0.4 μM

MethodIC50