Peptide Database

Peptide NameSLAY-screened peptide P2305

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC94H140N24O25

DescriptionStandard

        PIEYLLVSLNHHYLSHA
    

Molecular Weight2006.26 Da

Isoelectric Point (pI)6.29

Net Charge (pH 7.0)-0.78

Net Charge (pH 7.4) -0.99

Charge Density (pH 7.0) -0.0458

GRAVY Index0.19

Hydrophobic Moment 0.31

Boman Index0.29

Instability Index61.11

Aliphatic Index 137.65

Aromaticity 0.1176

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 762.28

LogP -4.00

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 61.0

Heavy Atoms 143.0

Ring Count 6.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007925 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/