Peptide Database

Peptide NameUperin-2.2

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC88H151N25O23

DescriptionStandard

        GFVDLAKKVVGGIRNALGI
    

Molecular Weight1927.29 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.0926

GRAVY Index0.77

Hydrophobic Moment 0.66

Boman Index0.28

Instability Index-3.32

Aliphatic Index 138.42

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 781.45

LogP -6.04

H-bond Donors 27.0

H-bond Acceptors 25.0

Rotatable Bonds 66.0

Heavy Atoms 136.0

Ring Count 1.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0309257 VERIFIED: YES

Provenance & Taxonomy

OrganismUperoleia inundata [Animal]

FamilyUperin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetS.uberis

RECORD: Rec_0316284 VERIFIED: YES

Provenance & Taxonomy

OrganismUperoleia inundata [Animal]

FamilyUperin

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetStaphylococcus aureus and Streptococcus uberis

RECORD: Rec_0328064 VERIFIED: YES

Provenance & Taxonomy

OrganismUperoleia inundata [Animal]

FamilyUperin

Structure & Mods

ConfigSingle-chain peptide backbone represented as a linear sequence entry [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetL.innocua

RECORD: Rec_0392202 VERIFIED: NO

Provenance & Taxonomy

OrganismUperoleia inundata [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0392657 VERIFIED: NO

Provenance & Taxonomy

OrganismUperoleia inundata [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Amphibian defense peptide Antibiotic Antimicrobial Anti-Gram-negative Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetBacillus cereus, Escherichia coli, Listeria innocua, Micrococcus luteus, Pasteurella haemolytica, Staphylococcus aureus

MethodQualitative functional evidence

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