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MYP_144285
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Basic Information
Bacteriocin glycocin F (GccF)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Standard
43 amino acids
C210H289N55O62S7
Standard
Sequence
KPAWCWYTLAMCGAGYDSGTCDYMYSHCFGIKHHSSGSSSYHC
Physicochemical Analysis
4800.33 Da
7.04
0.05
-0.44
0.0013
-0.32
0.24
0.14
52.65
25.12
0.1860
18450.00
18700.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1832.89
-20.06
72.0
73.0
144.0
334.0
15.0
42.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0045340 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus plantarum [Bacterium]
Bacteriocin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
L.plantarum ATCC 8014
PMID21251913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21251913/
RECORD: Rec_0119047 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus plantarum [Bacterium]
1590; 0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-28; 12-21
Bio-Activity Profile
Antimicrobial Host defense
PaperPDB 2KUY structural record; NMR; chain A; residues 1-43
RECORD: Rec_0119459 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
PaperBACTIBASE second release: a database and tool platform for bacteriocin characterization PMID20105292 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20105292/
RECORD: Rec_0122079 VERIFIED: YES
Provenance & Taxonomy
Lactiplantibacillus plantarum [Plant]
Bacteriocin
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Acetylation
Glycosylation occurs at both Ser and Cys (modified by an N-acetylglucosamine beta-O-linked to Ser18, and an N-acetylhexosamine S-linked to C-terminal Cys43). There are two disulfide bonds: C5-C28 and C12-C21
Bio-Activity Profile
Antimicrobial
Rather, purified GccF caused rapid and sustained bacteriostasis
~0.002 μM
IC50
PaperCysteine S-glycosylation, a new post-translational modification found in glycopeptide bacteriocins
RECORD: Rec_0194413 VERIFIED: YES
Provenance & Taxonomy
Lactobacillus plantarum [Bacterium]
Bacteriocin
1590
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Lactobacillus plantarum ATCC 8014
0.002 μM
IC50
PaperPubMed PMID: 21395300 | PubMed PMID: 21251913 PMID21395300;21251913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21395300/
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