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MYP_144261
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Basic Information
Phakellistatin 22
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
10 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
PPXFELPPYI
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012176 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Methionine sulfone
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0016181 VERIFIED: YES
Provenance & Taxonomy
Stylissa flabelliformis [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Methionine sulfone
Bio-Activity Profile
Antimicrobial Anticancer
K562
0.17 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0033931 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Methionine sulfone
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: SK-HEP-1
0.041 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0041035 VERIFIED: YES
Provenance & Taxonomy
Stylissa flabelliformis [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Methionine sulfone
Bio-Activity Profile
Antimicrobial Anticancer
MDA-MB-231
0.4 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
RECORD: Rec_0048290 VERIFIED: YES
Provenance & Taxonomy
Phakellia fusca [Animal]
Phakellistatin
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=Methionine sulfone
Bio-Activity Profile
Antimicrobial Anticancer
K562
0.17 μM
IC50
PMID29893558 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29893558/
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